The Lancet in conversation with

Do you believe in meta-analysis? Oct 29, 2026 22:49 Niall Boyce welcomes Professor Stuart Pocock, author of two Lancet papers, published 35 years apart: 1991's "Can meta-analyses be trusted?" and 2026's "What makes a meta-analysis believable?" They discuss what makes a trustworthy meta, and how the smart clinician should use the totality of evidence to inform clinical care. Click here to read the full article: https://www.thelancet.com/journals/lan

How should we manage cardiovascular conditions in pregnancy? Aug 27, 2026 32:22 What cardiovascular issues can women experience in pregnancy, and why? Lancet editors Niall Boyce and Chloe Wilson talk with Professor Garima Sharma, one of the authors of a new Series of papers aiming to bring the cardiovascular health of pregnant women into the mainstream of primary and secondary care. Click here to read the full series: https://www.thelancet.com/journals/lancet/article/PIIS0140

What’s the story with mRNA vaccines? Jul 31, 2026 23:35 What are mRNA vaccine, how do they work, and how might they be used for in the future? And why is there a gap between the evidence and some people’s perception of their safety and efficacy? Niall Boyce from The Lancet talks to Anna Blakney, biomedical engineer and one of the authors of new Review paper "Safety and efficacy of mRNA vaccines: a mechanistic and public health perspective". Click here

What are cardiometabolic long-term conditions? Jul 10, 2026 19:16 What are cardiometabolic long-term conditions? To mark the publication of a new Lancet Series, editors Niall Boyce and Flávia Geraldes talk to Professor Kamlesh Khunti of the University of Leicester. They learn about a new way of conceptualising common medical conditions that has the potential to radically transform both health services and patient outcomes. Click here to read the full series: htt

Tania Nikolcheva, Gavin Giovannoni and Tharick Pascoal on the Special issue in Neurology May 31, 2026 32:34 In this episode of The Lancet In Conversation With, editors Niall Boyce and Bea Gómez Pérez-Nievas are joined by three leading researchers to discuss highlights from The Lancet's special issue on neurology. The conversation covers three landmark studies: the PADOVA trial of prasinezumab in early-stage Parkinson's disease, the ORATORIO-HAND study extending ocrelizumab treatment to wheelchair-using

Paul Spiegel: rethinking the humanitarian response to conflict and forced displacement May 19, 2026 31:51 Do we need to rethink our response to conflict and forced displacement? A new Lancet Commission radically rethinks policy, funding, and practical approaches to humanitarian crises. Chair Professor Paul Spiegel joins Niall Boyce from the Lancet to discuss the aims and recommendations of this Commission on one of the most pressing health issues of the 21st century. Click here to visit the commission

Can semaglutide be used to treat alcohol use disorder? May 2, 2026 31:49 The Lancet’s Niall Boyce and Jonathan Pimm, and eBioMedicine’s Kalypso Karastergiou discuss an exciting new potential treatment for alcohol use disorder: semaglutide. As new research is published in The Lancet, they go behind the headlines with lead author Professor Anders Fink-Jensen to ask what the study showed, and what its implications are for the future of addiction medicine. Click here to re

Louise Chappell and Na’ama Carlin on Personal Cancer Stories Feb 3, 2026 30:39 The uniqueness of each patient is at the heart of this year's World Cancer Day. Each cancer patient has their own hopes, dreams and fears. In this Podcast you will hear from two cancer survivors about their unique experience with cancer and the importance of personalised cancer care not only on their bodies but also on their lives. Continue this conversation on social! Follow us today at... https:

Susannah Stanway on the London Global Cancer Week Dec 19, 2025 24:04 In Conversation with The Lancet returns with Dr Susannah Stanway, honorary consultant medical oncologist at the Royal Marsden and honorary clinical senior lecturer in Education at the Institute of Cancer Research, reflecting on London Global Cancer Week 2025. This episode goes beyond event highlights to discuss the need for a global oncology agenda rooted in equity, evidence-based care, and value

Carlos Monteiro, Camila Corvalán, and Phil Baker on Ultra-Processed Foods and Human Health Dec 9, 2025 1:01:17 Ultra-processed foods are on the rise. Despite the emphasis placed on individual responsibility, our deteriorating diets are primarily the result of the sophisticated political tactics of a powerful global ultra-processed food industry. Addressing this urgent threat demands a coordinated response from the global public health community. So argues a 3-paper Series published in The Lancet that exami

Presented at ASH: the EPCORE FL-1 study on epcoritamab in follicular lymphoma Dec 7, 2025 13:03 Franck Morschhauser joins Ben Abbott of The Lancet to discuss the phase 3 EPCORE FL-1 study on epcoritamab, lenalidomide, and rituximab for relapsed or refractory follicular lymphoma, which is being presented at ASH 2025. Click here to read the full article: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02360-8/fulltext Continue this conversation on social! Follow us today at.

Presented at ESMO: the HARMONi-6 study on a bispecific antibody therapy for squamous NSCLC Oct 19, 2025 20:43 Shun Lu joins Ben Abbott of The Lancet to discuss the phase 3 HARMONi-6 trial of ivonescimab plus chemotherapy as first-line treatment in advanced squamous non-small-cell lung cancer, which is being presented at ESMO 2025. Click here to read the full article Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://faceb

Presented at ESMO: the POTOMAC study on immunotherapy in non-muscle-invasive bladder cancer Oct 17, 2025 22:09 Neal Shore joins Ben Abbott of The Lancet to discuss the phase 3 POTOMAC trial of durvalumab plus BCG in BCG-naïve, high-risk non-muscle-invasive bladder cancer, which is being presented at ESMO 2025. Click here to read the full article Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedic

Stephen Chan on the Lancet Commission on addressing the global hepatocellular carcinoma burden Jul 28, 2025 20:41 With the global burden of liver cancer growing, The Lancet has commissioned an international panel of experts to identify strategies to strengthen the prevention, surveillance, diagnosis, and treatment of liver cancer. Stephen Chan joins Ben Abbott of The Lancet to discuss the key messages of the Commission, which is published today on World Hepatitis Day. Read the full Commission: https://www.the

Rebecca Fitzgerald on biomarker risk stratification with capsule sponge in the surveillance of Barrett’s oesophagus Jul 24, 2025 27:15 Early detection of oesophageal adenocarcinoma improves outcomes. Patients with the precursor lesion, Barrett's oesophagus, are recommended to undergo regular endoscopic surveillance, a process that can be burdensome for patients and health services. Professor Rebecca Fitzgerald's team have developed a tool that may be able to improve Barrett's surveillance. She joins us to discuss her recent pros

ASCO 2025 Debrief Jun 11, 2025 14:44 Vania Wisdom, Senior Executive Editor at The Lancet and the journal's Oncology Ambassador, and Katherine Gourd, Acting Deputy Editor at The Lancet Oncology, join Leon Terner to share some of their experiences, impressions and highlights from this year's American Society of Clinical Oncology (ASCO) conference. If you haven't already, be sure to listen to Vania's pre-ASCO predictions podcast here:

Presented at ASCO: the first RCT of CAR T-cell therapy in solid tumours May 31, 2025 14:45 Changsong Qi joins Chloe Wilson and Ben Abbott of The Lancet to discuss their recently published phase 2 randomised controlled trial investigating Claudin-18 isoform 2-specific CAR T-cell therapy for previously treated advanced gastric or gastro-oesophageal junction cancer. Read the full article: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00860-8/fulltext?dgcid=buzzsprout_i

Previewing ASCO 2025 May 30, 2025 4:54 Vania Wisdom, Senior Executive Editor at The Lancet and the journal's Oncology Ambassador, joins Gavin Cleaver to discuss what's being published at this year's American Society of Clinical Oncology (ASCO) meeting, what she's excited to see at the conference, and why ASCO is so important to the field. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https:/

Francis Couturaud on treatment of venous thromboembolism Mar 14, 2025 28:30 Francis Couturaud joins Chloe Wilson of The Lancet to discuss the RENOVE trial, which looks at assessing the efficacy and safety of reduced-dose versus full-dose direct oral anticoagulants in patients in whom extended anticoagulation has been indicated. Read the full paper: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02842-3/fulltext?dgcid=buzzsprout_icw_podcast_generic_lan

Shawn St Peter on appendicectomy versus antibiotics for acute uncomplicated appendicitis in children Jan 27, 2025 16:01 This week, we discuss treatment approaches for uncomplicated appendicitis in children following the publication of a trial in our January 18th issue. Lead author Shawn St Peter, general paediatric surgeon and surgeon-in-chief at Children’s Mercy Hospital, Kansas City, spoke with Callam Davidson about the motivation behind the study, key findings, and what the results mean for clinical practice. R

Michael Heneka on passive anti-amyloid β immunotherapy in Alzheimer’s disease Jan 9, 2025 21:35 Michael Heneka joins Chloe Wilson and Bea Gomez Perez-Nievas of The Lancet to discuss a therapeutics paper discussing the opportunities and challenges of passive anti-amyloid β immunotherapy in Alzheimer's disease. Read the full article: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01883-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet Continue this conversation on soc

Nusrat Husain, Farah Lunat, and Fehmida Motala on postnatal depression in British south Asian women (the ROSHNI-2 trial) Oct 31, 2024 48:44 ROSHNI-2 was a multicentre, randomised controlled trial that investigated the efficacy of a culturally adapted, cognitive behavioural therapy-based intervention for postnatal depression in British south Asian women. Joining us to share their expertise and perspectives are chief investigator Professor Nusrat Husain, trial manager Farah Lunat, and service user representative Fehmida Motala. Read th

Rasha Al-Lamee and Shayna Chotai on ESC 2024 highlights Oct 10, 2024 40:18 Rasha Al-Lamee and Shayna Chotai join Chloe Wilson of The Lancet to discuss ESC Congress 2024 highlights. The papers featured on this podcast are: 1) https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01733-1/fulltext 2) https://www.nejm.org/doi/abs/10.1056/NEJMoa2409134 3) https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01454-5/abstract 4) https://www.nejm.org

Dr Oriol Mitjà and Dr Hypolite Muhindo Mavoko on mpox Sep 5, 2024 26:26 On August 14th, the World Health Organisation declared a public health emergency of international concern in relation to mpox. This was motivated, in part, by the emergence of a concerning new strain of mpox, clade 1b, which has spread rapidly across Central Africa. Joining me this week to discuss important clinical aspects of the current mpox outbreak are Dr Oriol Mitja, Associate Professor at th

Natasha Pocovi on the prevention of low back pain recurrence Aug 8, 2024 23:50 Natasha Pocovi joins Chloe Wilson of The Lancet to discuss a trial investigating a walking and education intervention for the prevention of low back pain recurrence in Australia (WalkBack). Read the full article: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00755-4?dgcid=buzzsprout_tlv_podcast_generic_lancet Continue this conversation on social! Follow us today at... https:/

Prasad Kulkarni on a vaccine against typhoid and paratyphoid May 2, 2024 18:06 Prasad Kulkarni joins Callam Davidson of The Lancet to discuss the safety and immunogenicity of a bivalent conjugate vaccine against typhoid and paratyphoid, following the publication of a phase 1 trial. Read the full article: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00249-6/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet Continue this conversation on social! Follow

$Patricia Campbell and Frans Rutten on heart failure with preserved ejection fraction$

Patricia Campbell and Frans Rutten on heart failure with preserved ejection fraction Mar 28, 2024 40:03 Patricia Campbell and Frans Rutten join Chloe Wilson for an educationally-focused podcast, discussing the key messages for clinical practice on heart failure with preserved ejection fraction. Read the full Seminar: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02756-3/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet Continue this conversation on social! Follow us today at

Lene Seidler on umbilical cord management at preterm birth Dec 21, 2023 14:49 Lene Seidler joins Callam Davidson of The Lancet to discuss umbilical cord clamping strategies at preterm birth following the publication of two systemic review and meta-analyses with individual participant data. Read the full articles: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02468-6/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet https://www.thelancet.com/journals

Emily Chew on the future of treatments for geographic atrophy Oct 26, 2023 18:26 Emily Chew joins Chloe Wilson of The Lancet to discuss the future of treatments for geographic atrophy following the publication of two randomised controlled trials of new drug treatments. Read the full article here: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01583-0/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet Continue this conversation on social! Follow us today

Simon Kyle on a new effective treatment for insomnia Aug 31, 2023 11:04 Simon Kyle joins Gavin Cleaver of The Lancet to discuss his paper on sleep restriction therapy as a new effective treatment for insomnia. Read the full article: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00683-9/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.c

Verna Vanderpuye and Isabelle Soerjomataram on International Women’s Day and cancer Mar 8, 2022 12:56 On this International Women's Day, Lancet editors and the co-chairs of the Women and Cancer Commission discuss the burden of women’s cancer on society and reflect on the questions the Commission is trying to answer. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://l

Nick James on the STAMPEDE trial Dec 23, 2021 14:56 Nick James discusses the key messages of the recent report from the STAMPEDE trial platform and the success of this platform in advancing the treatment of prostate cancer Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube

Jie Qiao (in Chinese) on reproductive health in China Jun 2, 2021 16:37 《柳叶刀》亚洲执行主编王辉对话《柳叶刀中国女性生殖、孕产妇、新生儿、儿童和青少年健康重大报告》共同主席乔杰院士。 Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

Jie Qiao (in English) on reproductive health in China Jun 2, 2021 16:40 Helena Wang discusses The Lancet Commission on women's reproductive, maternal, newborn, child and adolescent health (RMNCAH) in China with author Professor Jie Qiao. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/t

Siobhan Quenby & Arri Coomarasamy on miscarriage Apr 26, 2021 18:27 Siobhan Quenby & Arri Coomarasamy discuss the key findings from The Lancet's new Series on miscarriage. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

Muir Gray Feb 25, 2021 16:41 On the 50th anniversary of the Inverse Care Law, Professor Sir Muir Gray joins Gavin Cleaver to discuss the continuing importance of the ICL, and notions of value and quality in health care. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lan

Mary Bassett Feb 11, 2021 25:20 The Lancet's new Commission, Public Policy and Health in the Trump Era, looks back at the effects of the last four years on the health of the USA. One of the authors of the Commission, Mary Bassett (Harvard University) joins us to talk about the Commission findings and wider issues facing the USA. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://in

Richard Horton on the Oxford vaccine phase 3 trial Dec 8, 2020 11:32 Editor-in-chief of The Lancet, Richard Horton, discusses the results of the Oxford vaccine's phase 3 trial. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

Renee Salas Dec 2, 2020 17:12 Renee Salas, leader of the Lancet Countdown policy brief in the US, discusses the climate problems facing the US, the issues of the last four years, and the reasons to be optimistic about the future. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/compan

Rafael Lozano and Margaret Kruk Sep 2, 2020 22:52 Universal health coverage (UHC) is a vital facet of healthcare across the world, and a new Global Burden of Disease paper seeks to measure its spread. The Lancet spoke with author Rafael Lozano and linked Comment author Margaret Kruk about efforts to analyse and measure UHC. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetg

Richard Horton Jul 20, 2020 11:22 The Lancet Editor-in-Chief Richard Horton explains the current status of the Oxford and China COVID-19 vaccines, including an overview of current progress and the next steps for both. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet htt

Kathleen O’Reilly and Stein Emil Vollset Jul 14, 2020 23:21 The new Global Burden of Disease paper forecasts major alterations in worldwide population over the next few decades. We ask Kathleen O’Reilly, of LSHTM, how models are made and how you account for a changing world, and we speak with paper author Stein Emil Vollset of IHME about the implications of his predictions. Continue this conversation on social! Follow us today at... https://thelancet.bsky.

Rosanna Peeling Jul 7, 2020 21:37 Professor Rosanna Peeling discusses the implications of seroprevalence results from recent COVID-19 antibody studies. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

Bin Cao (in Chinese) Mar 9, 2020 18:11 柳叶刀亚洲执行主编王辉跟曹彬教授关于2019冠状病毒感染住院患者临床发病过程和死亡危险因素的讨论 Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

Bin Cao Mar 9, 2020 11:16 The Asia Executive Editor of The Lancet, Helena Hui Wang, chats with Bin Cao about clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https:

Richard Horton, Sarah Dalglish, and Grace Gatera Feb 19, 2020 16:25 Richard Horton, Sarah Dalglish, and Grace Gatera talk about the future for children alive today, alongside findings from the new Commission. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

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