The Lancet Rheumatology in conversation with

Mrinalini Dey on the association between health literacy and outcomes in people with inflammatory arthritis Jul 21, 2026 1178 In August’s episode, Dr Mrinalini Dey from the Centre for Rheumatic Diseases at King’s College London discusses her recent publication on the association between health literacy and outcomes in people with inflammatory arthritis in England. Health literacy—the ability to access, understand, evaluate, and use health information and services in ways that promote and maintain good health and wellbein

Enpatoran for Cutaneous or Systemic Lupus with Eric Morand Jun 22, 2026 1074 In today’s episode Professor Eric Morand discusses the results of Cohort A and Cohort B of the WILLOW trial which investigated the efficacy and safety of enpatoran, a novel, oral small molecule inhibitor of Toll-like receptors 7 and 8 (TLR 7/8) in patients with cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE). The interferon pathway has been implicated in both CLE and SLE

Tue Wenzel Kragstrup on GLP-1 and DPP-4 in the synovial fluid of patients with rheumatic disease May 25, 2026 912 In this month’s podcast, we explore Associate Professor Kragstrup’s recent proof-of-concept study which reports glucagon-like peptide-1 (GLP-1) concentrations and dipeptidyl peptidase-4 (DPP-4) activity in paired plasma and synovial fluid from patients with rheumatoid arthritis and spondyloarthritis and discuss whether there may be potential for intra-articular GLP-1 receptor agonist injections in

Dirk Foell on trends in paediatric rheumatology care across Europe Apr 21, 2026 960 In this episode, Professor Dirk Foell from University Hospital Münster unpacks the findings from a recent Europe-wide survey examining trends in paediatric rheumatology care. Despite significant scientific advances, delivering consistent, high-quality care for children with rheumatic and musculoskeletal diseases remains a challenge. Drawing on Professor Foell's recent Viewpoint, we discuss variati

Jon Lampa on patient-reported outcomes from the NORD-STAR trial Mar 23, 2026 926 As part of The Lancet Rheumatology’s special issue on public and patient involvement in rheumatology, in this month’s episode, Aisling talks to Professor Jon Lampa about his recent publication on the patient-reported outcomes from the NORD-STAR trial. The 2023 NORD-STAR trial was the first randomised trial to compare three different biological DMARDs, all in combination with methotrexate with act

Coziana Ciurtin on long-term outcomes of childhood-onset Sjögren’s disease Feb 23, 2026 2148 In this month’s episode we discuss childhood-onset Sjögren’s disease-a rare and under-researched rheumatic condition. Lack of robust clinical and immunological characterisation of this condition alongside assessment of its impact on quality of life has significantly hampered progress in the delivery of high-quality research and evidence-based recommendations for care. There are currently no stu

Fiona Pearce and Rachel Tattersall on HLH mortality rates in Europe Jan 26, 2026 2076 This months episode covers Hemophagocytic lymphohistiocytosis, or HLH, a rare, life-threatening disorder characterised by dysregulated immune activity resulting in systemic inflammation, tissue damage and multiorgan failure which affects both children and adults. The annual prevalence of HLH in England is around 2 per million people in the adult population, with an overall 1-year survival rate of

John Isaacs and Josh Bennett on sarcopenia in rheumatoid arthritis Dec 15, 2025 1165 During this episode, Dr John Isaacs and Dr Josh Bennett from Newcastle University and the NIHR Newcastle Biomedical Research Centre, discuss sarcopenia - an age-related loss of muscle mass and strength. Sarcopenia is relatively common in rheumatoid arthritis, with a prevalence ranging from 4·5% to 44% of people with rheumatoid arthritis, depending on the definition of sarcopenia used. Rheumatoid s

Dr Samuel Bitoun on machine learning to classify the focus score and Sjögren’s disease Nov 17, 2025 672 This month's episode covers Sjögren’s disease—an autoimmune condition that primarily affects areas of the body that produce fluids, such as tears and saliva. The cause of the disease isn’t understood. Currently there are no licensed drugs to treat the disease, but phase 2 clinical trials have reported encouraging results, and phase 3 trials are underway. Dr Samuel Bitoun, from the University of P

Ryan Hum on synovial immunopathology in psoriatic arthritis Oct 20, 2025 1608 In today's episode, Sophie discusses psoriatic arthritis with Dr Ryan Hum from The University of Manchester. Psoriatic arthritis affects between 0.1% and 1% of the general population globally, and appears to be more prevalent in certain regions. It affects men and women equally and typically appears between the ages of 30 and 55 years. Psoriatic arthritis tends to be more common in people with ps

Scott Uhlrich on personalised gait retraining for knee osteoarthritis Sep 22, 2025 986 In this episode, we’re tackling a condition that affects over 374 million people worldwide—knee osteoarthritis (OA). As the most common site of OA, knee OA is a leading cause of disability and accounts for more than 12 million disability-adjusted life years globally. With prevalence rising steadily due to aging populations and increasing obesity rates, the burden of knee OA is projected to climb e

Mark Hancock on low back pain Aug 18, 2025 620 In this episode, we'll be discussing an issue that affects millions of people globally - low back pain. We will find out why the burden of low back pain is so high, why current management is so ineffective, what we can do from a research and care perspective to improve outcomes for patients, and whether prevention is the way forward. We’ll also discuss a couple of papers that have been recently p

Vibeke Strand on polymyalgia rheumatica Jul 21, 2025 692 In this episode Professor Vibeke Strand discusses polymyalgia rheumatica (or PMR), a common inflammatory rheumatic disease that significantly impairs patients’ quality of life, causing fatigue, pain, and physical disability, especially in relapsing cases that often require long-term glucocorticoid treatment. However, these treatments come with considerable side effects, and many patients do not re

Xue Li on access to biologics in the Asia-Pacific region Jun 20, 2025 1171 This is a joint podcast between The Lancet Rheumatology and The Lancet Regional Health - Western Pacific with Prof Xue Li. Biologics have become a mainstay of treatment in Rheumatology in Western populations, but in many parts of Asia, especially lower-and-middle-income countries, there remains substantial inequity in access due to differences in availability and affordability. In this episode, w

Sinisa Savic on treatment outcomes in VEXAS syndrome Jun 16, 2025 727 In this podcast, Professor Savic talks about his recent publication that looks at treatment outcomes in patients with VEXAS syndrome, as well as what clinicians should look out for in patients (red flags), and future priorities for research. VEXAS syndrome (short for Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome) was first described in 2020. It’s a rare, and often-life threate

Fabian Müller and Melanie Hagen on a newly discovered toxicity of CD-19 targeting CAR T-cell therapy Jun 3, 2025 1250 This is the third and final episode of our mini-series on cell-based therapies in rheumatology, with Professor Fabian Müller and Dr Melanie Hagen from the Erlangen University, Germany. We discuss their recently published a study on a newly discovered toxicity of CD-19 targeting CAR T-cell therapy in patients with autoimmune disease, as well as the recent successes of CAR T-cell therapy, ideal pati

Dominique Farge on allogeneic umbilical cord-derived mesenchymal stromal cells for systemic lupus erythematosus Apr 25, 2025 1565 This is the second episode of a mini series on cell-based therapies in rheumatology, with Prof. Dominique Farge discussing the use of allogeneic umbilical cord-derived mesenchymal stromal cells (MSCs) as treatment for systemic lupus erythematosus (SLE). We cover the limited options currently available for people with severe or refractory SLE, the complexities in using MSCs, Prof. Farge's recent s

$Rebecca Marsh and Grant Schulert on allogeneic HSCT for children with refractory sJIA and associated lung disease$

Rebecca Marsh and Grant Schulert on allogeneic HSCT for children with refractory sJIA and associated lung disease Mar 24, 2025 1110 The first episode of a mini series on cell-based therapies in rheumatology, with Prof Rebecca Marsh and Grant Schulert discussing the use of allogeneic haematopoietic stem-cell transplantation for children with refractory systemic juvenile idiopathic arthritis and associated lung disease. Read the full article: https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(24)00275-3/fulltext?dgc

Bryant England on advanced therapies in US veterans with rheumatoid arthritis-associated interstitial lung disease Feb 24, 2025 510 Dr Bryant England discusses the use of TNF-inhibitor versus non-TNF inhibitor biological or targeted synthetic DMARDs for treatment of rheumatoid arthritis-associated ILD, and the effects on survival and respiratory hospitalisation outcomes. Read the full article: https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(24)00265-0/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanrhe Continu

Brooke Conley and Ivan Lin on the development of arthritis educational resources for Aboriginal and Torres Strait Islander peoples in Australia Jan 27, 2025 1110 Dr Brooke Conley and Associate Professor Ivan Lin discuss their recent study on integrating evidence from lived experience of Aboriginal people and clinical practice guidelines to develop arthritis educational resources. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https:

Mark Russell and Sherry Yang on the inequities in rheumatological care in the UK and USA Dec 23, 2024 1528 Dr Mark Russell and Sherry Yang discuss the factors influencing initiation of biologics in underserved populations with rheumatoid arthritis in the UK, how historical redlining and present-day racialised economic segregation affects health-care utilisation of adults with rheumatic diseases in the USA, and health inequities seen in rheumatology more broadly. Read the full article: https://www.thel

Quirine Dumoulin on the 4-year data from the TREAT-EARLIER trial Nov 25, 2024 938 Dr Quirine Dumoulin discusses the efficacy of a 1-year course of methotrexate on the development of rheumatoid arthritis in ACPA-negative people with clinically suspect arthralgia and predicted increased risk of rheumatoid arthritis. Read the full article: https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(24)00196-6?dgcid=buzzsprout_icw_podcast_generic_lanrhe Continue this conversat

Sebastian Sattui on older adults with ANCA-associated vasculitis Oct 21, 2024 1554 Dr Sebastian Sattui discusses the effects of age and frailty on the risks of end-stage renal disease, death, and severe infection in older adults with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Read the full article: https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(24)00193-0/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanrhe Continue this conversation on s

Celebrating 5 years of The Lancet Rheumatology with Oliver Distler, Laura Coates, and David Liew Sep 23, 2024 3482 To celebrate 5 years of The Lancet Rheumatology, international advisory board members Oliver Distler, Laura Coates, and David Liew discuss recent progress made, challenges to overcome, and future directions in rheumatology. Read the associated Editorial: https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(24)00245-5/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanrhe Continue this co

Karen Schreiber, Ian Giles, and Angela Tincani on the Pregnancy and Rheumatic Diseases Series Jul 22, 2024 2073 Dr Karen Schreiber, Professor Ian Giles, and Professor Angela Tincani discuss the Series on Pregnancy and Rheumatic Diseases, including the use of DMARDs during pregnancy, study design and conduct, and outcomes for children born to mothers with rheumatic diseases. Read the Series: https://thelancet.com/series/pregnancy-rheumatic-diseases?dgcid=buzzsprout_icw_podcast_generic_lanrhe Continue this c

Dr Maria Tektonidou on cardiovascular risk factors in systemic lupus erythematosus Jun 17, 2024 680 Dr Maria Tektonidou discusses the results of a cross-sectional analysis of international data on cardiovascular risk factors in systemic lupus erythematosus. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancet

Rosemary Hollick on improving services for adults with rare autoimmune rheumatic diseases May 21, 2024 977 Dr Rosemary Hollick, University of Aberdeen, discusses a mixed-methods study on key health system components associated with improved outcomes to inform the re-configuration of services for adults with rare autoimmune rheumatic diseases. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedi

Clinical Realities: Heather Van Epps, Anna Clark, Lola Falasinnu, David Liew, and Puja Mehta Jan 18, 2023 1535 Editors Heather Van Epps and Anna Clark join guest hosts Lola Falasinnu, David Liew, and Puja Mehta to reflect on the progress of The Lancet Rheumatology and share their vision for the future. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-

Clinical Realities: Sex and Gender in Research Design and Reporting from The Lancet Summit Oct 12, 2022 2333 Dr Shirin Heidari, Prof James Wason, Dr Karen Schreiber, and Prof Cheryl Barnabe join guest host Dr David Liew to discuss how sex and gender impact research design and reporting and improvements that can be made. Learn more: The Lancet Summit: Sex and gender in rheumatology Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgr

Clinical Realities: Randy Cron, Chandrika Bhat, and Puja Mehta Aug 25, 2022 1987 Drs. Randy Cron and Chandrika Bhat join guest host Dr Puja Mehta to discuss the opportunities and challenges of cross-speciality research. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

Clinical Realities: Michael Weisman and Lola Falasinnu Jul 28, 2022 2120 Prof Michael Weisman joins guest host Dr Lola Falasinnu to discuss the challenges of conducting clinical trials in rheumatology and recent developments in trial design. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.co

Clinical Realities: Catherine Nelson-Piercy and Lizemarie Wium on obstetric medicine in rheumatic diseases Jun 23, 2022 1900 Prof Catherine Nelson-Piercy and Dr Lizemarie Wium join guest host Dr Puja Mehta to discuss the importance and challenges of obstetric medicine in rheumatic diseases. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com

Clinical Realities: Greta Lindenmayer, Stephen Brady, and Onika Paolucci on caring for Australian Aboriginal patients with lupus May 31, 2022 2202 Greta Lindenmayer, Stephen Brady, and Onika Paolucci join guest host David Liew to discuss specialist considerations for the care of Australian Aboriginal patients with lupus. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://you

Clinical Realities: Duncan Porter and Shahir Hamdulay discuss challenges facing UK rheumatology care in 2022 Apr 25, 2022 1748 Clinical Realities: Duncan Porter and Shahir Hamdulay discuss the challenges facing rheumatology care in the UK in 2022, and what's needed to improve care in the coming years. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://yo

Clinical Realities: Thomas Bush and Lola Falasinnu on the health consequences of climate hazards for patients with rheumatic diseases Mar 24, 2022 1414 Dr. Thomas Bush joins guest host Dr. Lola Falasinnu to discuss climate change and the potential adverse health effects of climate hazards for patients with rheumatic diseases. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://yo

Clinical Realities: Coziana Ciurtin, Kate Webb, and Puja Mehta on transitional care for adolescent patients with rheumatic diseases Feb 24, 2022 1880 Dr. Coziana Ciurtin and Dr. Kate Webb join guest host Dr. Puja Mehta to discuss the challenges and opportunities involved in transitional care for adolescent patients with rheumatic diseases as they progress to adulthood. Read the profile of Puja: Puja Mehta: taking the path untrodden Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com

Clinical Realities: Dzifa Dey and David Liew on specialist rheumatology care in Ghana Jan 27, 2022 1766 Dr. Dzifa Dey joins guest host Dr. David Liew to discuss innovations in providing specialist rheumatology care and patient education in Ghana, and how her experiences in Africa could help inform development of rheumatology care in other low-resource settings. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://face

Clinical Realities: Eric Peters and Jinoos Yazdani on rheumatology care for undocumented immigrants Dec 22, 2021 1409 Dr. Eric Peters and Prof. Jinoos Yazdani join Editor-in-Chief Heather Van Epps to discuss the challenges of providing specialist rheumatology care to undocumented immigrants in the USA. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet

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