The Lancet Gastroenterology & Hepatology in conversation with

Frank Ruemmele on a trial of cyclic exclusive enteral nutrition versus partial enteral nutrition to maintain remission in paediatric Crohn's disease Aug 13, 2026 1369 In children with Crohn’s disease who achieve remission through exclusive enteral nutrition, what's the optimal dietary therapy to maintain remission without the use of medication or surgery? Frank Ruemmele (Université Paris Cité) talks through the CD-Hope randomised controlled trial and its implications for clinical practice. Click here to read the full article: https://www.thelancet.com/journals/

Aleksander Krag on the utility of PEth for subclassifying individuals at risk of steatotic liver disease Feb 23, 2026 1220 Steatotic liver disease labels hinge on alcohol intake, but self-report is often inaccurate. In this episode, Aleksander Krag (Odense University Hospital) discusses a large Danish study using phosphatidylethanol (PEth), a direct blood biomarker of recent drinking, showing substantial underestimation and potential reclassification from MASLD to MetALD/ALD. Click here to read the full article: https

Dina Kao on a trial of lyophilised sterile faecal filtrate versus lyophilised conventional donor stool for recurrent Clostridiodes difficile infection Nov 28, 2025 955 Can bacteria-free, sterile faecal filtrate match conventional faecal microbiota transplantation for recurrent C difficile infection? Dina Kao (University of Alberta) unpacks a landmark multicentre trial that tested this hypothesis, and we discuss what it tells us about the role of living organisms in the therapeutic effects of microbiota-based therapies. Click here to read the full article: https:

Premysl Bercik on a double-blind crossover trial of gluten and wheat in IBS Nov 20, 2025 981 Do wheat or gluten trigger IBS symptoms? We spoke to Premysl Bercik about a randomised, double-blind, sham-controlled crossover trial that challenged adults with IBS—who reported benefit from a gluten-free diet—with wheat, gluten, or a gluten-free sham to test symptom and behavioural responses. Click here to read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25

Julia Mayerle on the validation of plasma multimetabolite signatures for patients at risk of or with suspected pancreatic ductal adenocarcinoma Jun 19, 2025 1612 Can a multi-metabolite blood test improve early pancreatic cancer detection? We spoke to Julia Mayerle about the METAPAC study, which sought to validate the ability of plasma metabolic signatures to find resectable tumors and reduce unnecessary invasive procedures in high-risk patients. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00056-1/fulltext?dgcid

Salvatore Piano on the global epidemiology of acute kidney injury in hospitalised patients with decompensated cirrhosis Apr 9, 2025 1145 How does acute kidney injury presentation and management differ globally for patients hospitalised with cirrhosis? We spoke to Salvatore Piano, corresponding author of the landmark International Club of Ascites GLOBAL AKI study, about new data on regional variations in severity, phenotype, treatment, and outcomes across 5 continents. Read the full article: https://www.thelancet.com/journals/langa

John Chia on the ASCOLT trial of adjuvant aspirin for colorectal cancer Mar 6, 2025 809 John Chia discusses the results of the ASCOLT trial, which explored the effect of aspirin after completion of standard adjuvant therapy for patients with colorectal cancer. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00387-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social! Follow us today at... https://bsky.a

Hannes Hagström on screening for advanced liver fibrosis alongside retina scanning in people with type 2 diabetes Jan 10, 2025 1283 Hannes Hagström discusses a study investigating the feasibility of screening for advanced liver fibrosis alongside retina scanning in people with type 2 diabetes. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00313-3/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social! Follow us today at... https://bsky.app/profil

Cathy Lu on intestinal ultrasound for assessing and monitoring Crohn’s disease small bowel strictures Dec 12, 2024 675 Cathy Lu (University of Calgary) discusses a consensus statement on the use of intestinal ultrasound for assessing and monitoring small bowel strictures in Crohn's disease. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00265-6/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social! Follow us today at... https://bsky.

$Peter De Cruz on the PREDICT-UC trial of intensified versus standard dose infliximab for steroid-refractory acute severe ulcerative colitis$

Peter De Cruz on the PREDICT-UC trial of intensified versus standard dose infliximab for steroid-refractory acute severe ulcerative colitis Nov 6, 2024 882 Peter De Cruz (University of Melbourne) discusses the PREDICT-UC trial of intensified versus standard dose infliximab induction therapy for steroid-refractory acute severe ulcerative colitis. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00200-0?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social! Follow us today at... htt

Shahida Din and Beatriz Gros on the harms associated with receiving placebo in trials of drugs for inflammatory bowel disease Nov 1, 2024 2055 Shahida Din (Western General Hospital, Edinburgh) and Beatriz Gros (Reina Sofía University Hospital, Cordoba) discuss two new papers on the harms associated with receiving placebo in induction and maintenance trials of biological therapies and small molecules in inflammatory bowel disease. Read the full articles: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00264-4/fulltext?

Arndt Vogel on the NALIRICC trial of nanoliposomal irinotecan in pretreated advanced biliary tract cancer Jul 31, 2024 1103 Arndt Vogel (Toronto General Hospital) discusses the NALIRICC trial of nanoliposomal irinotecan added to fluorouracil plus leucovorin in patients with cholangiocarcinoma and gallbladder carcinoma previously treated with gemcitabine-based therapies. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00119-5?dgcid=buzzsprout_icw_podcast_generic_langas Continue

Nancy Baxter on the duration of colorectal cancer risk reduction with a complete colonoscopy Jul 1, 2024 1505 Nancy Baxter (University of Melbourne) discusses a population-based study on the duration of risk reduction in colorectal cancer incidence and mortality after a complete colonoscopy. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00084-0?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social! Follow us today at... https://bsky

Sanna Nybacka and Magnus Simrén on a trial of low FODMAP diets versus low carbohydrate diets in IBS May 17, 2024 1396 Sanna Nybacka and Magnus Simrén (University of Gothenburg) discuss the CARIBS randomised controlled trial of a low FODMAP diet versus a low-carbohydrate diet versus pharmacological treatment in IBS. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00045-1/fulltext?dgcid=buzzsprout_tlv_podcast_generic_langas Continue this conversation on social! Follow us

Nuru Noor on the PROFILE trial of biomarker-stratified treatment in newly diagnosed Crohn’s disease May 7, 2024 1195 Nuru Noor (University of Cambridge) discusses the PROFILE trial of biomarker-stratified treatment strategies in people with newly diagnosed Crohn's disease. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00034-7/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social! Follow us today at... https://bsky.app/profile/lanc

Yusuke Shimakawa on a simple score for hepatitis B treatment eligibility in Africa Apr 22, 2024 1254 Yusuke Shimakawa (Institut Pasteur) discusses the development and evaluation of a simple score for hepatitis B treatment eligibility in Africa. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00449-1?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.bsky.socia

Mads Israelsen on validating the new steatotic liver disease nomenclature in people with excessive alcohol intake Mar 12, 2024 999 Mads Israelsen (Odense University Hospital) discusses a study to validate the new nomenclature of steatotic liver disease in patients with a history of excessive alcohol intake. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00443-0/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social! Follow us today at... https://

Louise Dye on the role of expectancy and gluten in non-coeliac gluten sensitivity Mar 1, 2024 1399 Louise Dye (University of Leeds) discusses a trial exploring the role of expectancy and gluten ingestion on symptoms in people with non-coeliac gluten sensitivity. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00317-5/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social! Follow us today at... https://bsky.app/profi

Tzu-Chan Hong on the primary antibiotic resistance of Helicobacter pylori in the Asia-Pacific region Dec 19, 2023 880 Tzu-Chan Hong (National Taiwan University Cancer Centre) discusses a systematic review and meta-analysis on primary antibiotic resistance of Helicobacter pylori between 1990 and 2022 in the Asia-Pacific region. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00281-9/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social!

Sarah Moen on metachronous colorectal cancer risk according to Lynch syndrome pathogenic variant after colectomy Nov 29, 2023 885 Sarah Moen (Erasmus University Medical Center) discusses a retrospective cohort study examining the risk of metachronous colorectal cancer after partial or extensive colectomy in carriers of different pathogenic Lynch syndrome variants. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00228-5/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue th

Anna Emilie Kann on the causes of mortality in patients with alcohol-related liver disease Oct 12, 2023 979 Anna Emilie Kann (Zealand University Hospital, Denmark) discusses a population-based study done in Denmark exploring the causes of mortality in patients with alcohol-related liver disease. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00192-9/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social! Follow us today at.

Robert Krouse on surgical versus non-surgical management of malignant bowel obstruction Sep 13, 2023 991 Robert Krouse (University of Pennsylvania) discusses the pragmatic S1316 trial of surgical versus non-surgical management for patients with malignant small bowel obstruction. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00191-7/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social! Follow us today at... https://bsk

Marc Rothenberg on a trial of benralizumab in eosinophilic gastritis Aug 10, 2023 869 Marc Rothenberg (University of Cincinnati College of Medicine) discusses a new trial assessing the efficacy and safety of benralizumab in patients with eosinophilic gastritis, and how the surprising findings might change our understanding of eosinophilic gastrointestinal diseases. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00145-0/fulltext?dgcid=buzz

Michael Pavlides on non-invasive tests for predicting clinical outcomes in non-alcoholic fatty liver disease Jul 12, 2023 1061 Michael Pavlides (University of Oxford) discusses work by the LITMUS Consortium on the prognostic performance of non-invasive tests in patients with non-alcoholic fatty liver disease. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00017-1/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social! Follow us today at... ht

Jasmohan Bajaj on global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis Jun 7, 2023 768 Jasmohan Bajaj (Virginia Commonwealth University and Central Virginia Veterans Healthcare System, Richmond, VA, USA), on behalf of the CLEARED Consortium, discusses a prospective observational cohort study examining global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-12

Adelina Artenie on the incidence of HIV and HCV in people who inject drugs May 10, 2023 1035 Adelina Artenie (University of Bristol, UK) discusses a systematic review and meta-analysis exploring the incidence of HIV and HCV among people who inject drugs, and associations with age and sex or gender. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00018-3/fulltext?dgcid=buzzsprout_icw_podcast_langas_lancet Continue this conversation on social! Fo

Johan Burisch on the costs of inflammatory bowel disease in high-income settings Apr 12, 2023 1200 Johan Burisch (Copenhagen University Hospital, Denmark) discusses the findings and recommendations of The Lancet Gastroenterology & Hepatology Commission on the cost of inflammatory bowel disease in high-income settings. Read the Commission here: The cost of inflammatory bowel disease in high-income settings Continue this conversation on social! Follow us today at... https://bsky.app/profil

Edouard Louis on the SPARE trial of infliximab or immunosuppressant withdrawal in Crohn’s disease Feb 8, 2023 1290 Edouard Louis (University Hospital CHU of Liège) discusses the SPARE randomised controlled trial of infliximab or concomitant immunosuppressant withdrawal in patients with Crohn’s disease. Read the full article: Withdrawal of infliximab or concomitant immunosuppressant therapy in patients with Crohn's disease on combination therapy (SPARE) Continue this conversation on social! Follow us today at

Paula Ghaneh on the ESPAC5 trial of neoadjuvant therapy in borderline resectable pancreatic cancer Jan 23, 2023 1220 Paula Ghaneh (University of Liverpool) discusses the ESPAC5 randomised controlled trial of short-course neoadjuvant therapy compared with immediate surgery for patients with borderline resectable pancreatic ductal adenocarcinoma. Read the full article: Immediate surgery compared with short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINOX, or chemoradiotherapy in patients with borderl

Dan Turner on vedolizumab in children with IBD Jan 6, 2023 891 Dan Turner (Shaare Zedek Medical Center) discusses the VEDOKIDS study on the safety, effectiveness, and dosing of vedolizumab in children with IBD. Read the full article: Outcomes, dosing, and predictors of vedolizumab treatment in children with inflammatory bowel disease (VEDOKIDS) Continue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.bsky.social

Simon Baunwall on faecal microbiota transplantation for first or second Clostridioides difficile infection Nov 9, 2022 921 Simon Baunwall (Aarhus University Hospital) discusses the EarlyFMT trial, a randomized placebo-controlled trial of faecal microbiota transplantation for first or second Clostridioides difficile infection. Read the full article: Faecal microbiota transplantation for first or second Clostridioides difficile infection (EarlyFMT) Continue this conversation on social! Follow us today at... https://b

James Alexander on immune responses to COVID-19 vaccination in patients with IBD Oct 5, 2022 828 James Alexander (Imperial College London) discusses the latest findings from the VIP case-control study, which is investigating COVID-19 vaccine immune responses in immunosuppressed patients with inflammatory bowel disease. Read the full article: COVID-19 vaccine-induced antibody and T-cell responses in immunosuppressed patients with inflammatory bowel disease after the third vaccine dose (VIP) C

Filip Knop on liraglutide for bile acid diarrhoea Sep 7, 2022 902 Filip Knop (University of Copenhagen) discusses a trial of liraglutide versus colesevelam for the treatment of bile acid diarrhoea. Read the full article: Safety and efficacy of liraglutide versus colesevelam for the treatment of bile acid diarrhoea: a randomised, double-blind, active-comparator, non-inferiority clinical trial Continue this conversation on social! Follow us today at... https://

Edward Kim on radiation segmentectomy for unresectable very early to early stage hepatocellular carcinoma Aug 4, 2022 846 Edward Kim (Icahn School of Medicine at Mount Sinai) discusses the single-arm RASER study of radiation segmentectomy for patients with unresectable very early to early stage hepatocellular carcinoma. Read the full article: Radiation segmentectomy for curative intent of unresectable very early to early stage hepatocellular carcinoma (RASER): a single-centre, single-arm study Continue this conversa

Joep Ijspeert on serrated polyp detection and risk of interval post-colonoscopy colorectal cancer Jul 6, 2022 626 Joep Ijspeert (Amsterdam University Medical Center) discusses a population-based study exploring the detection of proximal serrated polyps and interval post-colonoscopy colorectal cancer risk. Read the full article: Serrated polyp detection and risk of interval post-colonoscopy colorectal cancer: a population-based study Continue this conversation on social! Follow us today at... https://bsky.a

Elise Meima-van Praag on surgical closure for Crohn’s disease perianal fistulas Jun 14, 2022 590 Elise Meima-van Praag (Amsterdam University Medical Centre) discusses the PISA-II trial, investigating short-term anti-TNF therapy with surgical closure versus anti-TNF therapy for perianal fistulas in Crohn's disease. Read the full article: Short-term anti-TNF therapy with surgical closure versus anti-TNF therapy in the treatment of perianal fistulas in Crohn's disease (PISA-II) Continue this co

Juan Pablo Arab on NAFLD public health policies in the Americas May 9, 2022 1026 Juan Pablo Arab (Catholic University of Chile) discusses the current burden of NAFLD and the landscape of public health policies related to the disease in the Americas. Read the full article: The establishment of public health policies and the burden of non-alcoholic fatty liver disease in the Americas Continue this conversation on social! Follow us today at... https://bsky.app/profile/lancetga

Sarah Blach on hepatitis C virus epidemiology Apr 6, 2022 537 Sarah Blach (CDA Foundation) summarises the latest analysis of global hepatitis C virus epidemiology and cascade of care by the Polaris Observatory HCV Collaborators. Read the full article: Global change in hepatitis C virus prevalence and cascade of care between 2015 and 2020: a modelling study Continue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep

Sunil Solomon on a minimal monitoring approach for hepatitis C virus infection Mar 23, 2022 902 Sunil Solomon (Johns Hopkins University) discusses a study of a minimal monitoring approach for treating patients with hepatitis C virus infection. Read the full article: A minimal monitoring approach for the treatment of hepatitis C virus infection (ACTG A5360 [MINMON]): a phase 4, open-label, single-arm trial Continue this conversation on social! Follow us today at... https://bsky.app/profile

Rupert Leong on oral faecal microbiota transplantation in ulcerative colitis Mar 9, 2022 823 Rupert Leong (University of Sydney) discusses a new double-blind, randomised, placebo-controlled trial of oral faecal microbiota transplantation for patients with active ulcerative colitis. Read the full article: Lyophilised oral faecal microbiota transplantation for ulcerative colitis (LOTUS) Continue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.b

Swati Patel on early-onset colorectal cancer Feb 9, 2022 1167 Swati Patel (University of Colorado Anschutz Medical Center) discusses the epidemiology, clinical features, biology, risk factors, and opportunities for prevention and detection of early-onset colorectal cancers. Read the full article: The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection

Emilie Breekveldt on FIT-based screening for colorectal cancer in the Netherlands Dec 10, 2021 579 Emilie Breekveldt (Erasmus Medical Center, Netherlands) discusses a new analysis of the faecal immunochemical testing-based colorectal screening programme in the Netherlands. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(21)00368-X/fulltext Continue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.bsky.social

Wendy Spearman on non-alcoholic fatty liver disease in sub-Saharan Africa Nov 11, 2021 1354 Wendy Spearman (University of Cape Town) discusses a Series on the emergence of non-alcoholic fatty liver disease in Sub-Saharan Africa and the challenges it presents. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(21)00296-X/fulltext Continue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.bsky.social https://

Tim Vanuytsel on spore-forming probiotics in functional dyspepsia Sep 9, 2021 422 Tim Vanuytsel (University of Leuven) discusses a new trial of spore-forming probiotics in functional dyspepsia. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(21)00226-0/fulltext Continue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.bsky.social https://www.linkedin.com/company/langastro/ https://instagram.c

Raymond Henderson on the economic burden of colorectal cancer Aug 12, 2021 680 Raymond Henderson (Queen’s University Belfast) discusses a new analysis of the economic burden of colorectal cancer in Europe. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(21)00147-3/fulltext Continue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.bsky.social https://www.linkedin.com/company/langastro/ http

Sigurður Ólafsson on eliminating hepatitis C in Iceland Jun 22, 2021 789 Sigurður Ólafsson (Landspitali University Hospital) discusses newly published results from the nationwide programme to eliminate hepatitis C virus in Iceland. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(21)00137-0/fulltext Continue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.bsky.social https://www.link

Caroline Ovadia on intrahepatic cholestasis of pregnancy Jun 3, 2021 745 Caroline Ovadia (King’s College London) discusses an individual participant data meta-analysis on the treatment of intrahepatic cholestasis of pregnancy with ursodeoxycholic acid. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(21)00074-1/fulltext Continue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.bsky.soci

Matthew Akiyama on hepatitis C in prisons Apr 12, 2021 426 Matthew Akiyama (Montefiore Medical Center and Albert Einstein College of Medicine, USA) discusses a Review on hepatitis C elimination among people incarcerated in prisons. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(20)30365-4/fulltext Continue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.bsky.social htt

Monika Sarkar on reproductive health in women with liver disease Mar 11, 2021 495 Monika Sarkar (University of California San Francisco, USA) discusses her Comment on reproductive health in women with chronic liver disease. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(21)00055-8/fulltext Continue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.bsky.social https://www.linkedin.com/company/l

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