The Brain Podcast
The Brain Podcast highlights the rich and diverse neuroscience published in the Brain journals. Each episode features interviews with article authors, presented in an accessible and informal style. It is aimed at a broad audience including clinicians, researchers, students, neuroscientists, neurologists, neurosurgeons and psychiatrists. The show makes complex neuroscience research digestible and engaging.
Episodes
Vaccines mimicking conformational epitopes on α-synuclein fibrils provide immunity to Parkinson's disease
Welcome to the 38th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with senior author Professor Gültekin Tamgüney of the Brain article entitled: Vaccines mimicking conformational epitopes on α-synuclein fibrils provide immunity to Parkinson's disease We discuss the an exciting approach of structurally engineer
Propionic acid in multiple sclerosis: a phase 2b, double-blind, randomized placebo-controlled trial
Welcome to the 37th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author Dr Tobias Moser of the Brain article entitled: Propionic acid in multiple sclerosis: a phase 2b, double-blind, randomized placebo-controlled trial We discuss the an exciting results... Check out the full article on the Brain w
Distinct brain atrophy patterns in anti-IgLON5 disease
Welcome to the 36th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with senior author Dr Carsten Finke of the Brain article entitled: Brain atrophy patterns in anti-IgLON5 disease We discuss a fascinating article which examines clinical and imaging data related to anti-Iglon5 disease. This valuable contributio
Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity
Welcome to the 35th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author Dr Laetitia Marcadet and senior author Chantelle F Sephton of the Brain article entitled: Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity. We discuss the inte
Brain connectivity as a new target for Alzheimer's disease therapy?
Welcome to the 34th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author Dr Lorenzo Pini of the Brain article entitled: Brain connectivity as a new target for Alzheimer's disease therapy? We discuss a fascinating review into the literature examing brain connectivity in Alzheimer's disease as a biom
Models matter: human-specific roles of POU3F2 and Wnt Signalling in neurodevelopment
Welcome to the 33rd episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author Dr Courtney R Benoit and senior author Associate Professor Tracy L Young-Pearse of the Brain article entitled: POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population We discuss
Neurotransmitter-informed connectivity maps and predicting stroke functional outcome
Welcome to the 32th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author Dr Philipp J Koch of the Brain article entitled: Neurotransmitter-informed connectivity maps and their application for outcome inference after stroke We discuss a fascinating method to map neurotransmitter-informed brain netwo
Do seizures drive the neuropathology of dementia? Insights from a post-mortem study
Welcome to the 31th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author Dr Ifrah Zawar of the Brain article entitled: The association of seizure control with neuropathology in dementia We discuss an impressive post-mortem investigation of the link between seizures and the associated neuropathology
Investigating autoimmune mechanisms underlying progressive supranuclear palsy
Welcome to the 30th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with senior author Professor Gabor G Kovacs of the Brain article entitled: Midbrain cytotoxic T cells as a distinct neuropathological feature of progressive supranuclear palsy Listen to the fascinating insights exploring the autoimmune side of
Can transcriptional analysis detect efficient remyelination in multiple sclerosis?
Welcome to the 29th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author of the Brain article entitled: Distinct transcriptional changes distinguish efficient and poor remyelination in multiple sclerosis We are joined by Alida Chen for an interesting discussion into detecting transcriptional change
Nephrology Meets Neurology: how kidney health links to neurodegeneration
Welcome to the 28th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with three authors of the Brain article entitled: The relationship between kidney health and neurodegenerative diseases Ms Melody Zuo, Dr Le Chang and Professor Sarah A Gagliano Taliun grace the Brain podcast with an insightful discussion into
Understanding traumatic brain injury with high dimensional proteomic analysis
Welcome to the 27th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author Dr Lucia M Li of the Brain article entitled: High-dimensional proteomic analysis for pathophysiological classification of traumatic brain injury Listen to the fascinating insights into classifying traumatic brain injury (TBI)
Glymphatic homeostasis in heart failure- more in but not out?
Welcome to the 26th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author Dr Marios Kritsilis and senior author Associate Professor Iben Lundgaard of the Brain article entitled: Loss of glymphatic homeostasis in heart failure This academic duo from Lund University discuss their fascinating findings
Adult congenital myasthenic syndromes - discussing the diagnostic dilemma and other findings from a longitudinal cohort
Welcome to the 25th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with senior author Dr Tanya Stojkovic of the Brain article entitled: Congenital myasthenic syndromes in adults: clinical features, diagnosis and long-term prognosis Dr Stojkovic discusses findings from an impressive longitudinal adult cohort of
Nociceptors are functionally male or female: from mouse to monkey to man?
Welcome to the first episode of 2025 for The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with senior author Dr Frank Porreca of the Brain article entitled: Nociceptors are functionally male or female: from mouse to monkey to man? Dr Porreca discusses important findings into the sexual dimorphic nature of nociception and
Academic neurology in the UK: a plea to turn away from the precipice
Welcome to the 23nd episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. In this episode, we bring on authors Dr Helen Devine and Professor Simon Mead to discuss their opinion article entitled: Academic neurology in the UK: a plea to turn away from the precipice. The discussions covers the growing concerns regarding the future of academic neurology i
Can Epilepsy surgery improve or even reverse cognitive deficits in children with epilepsy?
Welcome to the 22nd episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with senior author Dr Torsten Baldeweg of the Brain article entitled: Long-term neuropsychological trajectories in children with epilepsy: does surgery halt decline? Dr Baldeweg discusses fascinating insight into the long term cognitive outcome
Anti-IgLon5 disease risk is mediated by HLA-DQB1*05 subtypes: when neuroimmunology meets neurodegeneration
Welcome to the 21th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with the first author Dr Selina Yogeshwar of the Brain article entitled: HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease Dr Yogeshwar offers exciting insight into the genetic mechanisms of a relatively recently dis
The essential Role of PAK2 in Myelinating the Peripheral Nervous System
Welcome to the 20th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with the final author Dr Jun Li of the Brain article entitled: PAK2 is necessary for myelination in the peripheral nervous system How are peripheral nerve cells myelinated and what proteins are invoved? Is there a difference between PAK1 and PA
How is the gut microbiota related to cognition and hippocampal neurogenesis in Alzheimer's disease?
Welcome to the 18th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author author Dr Stefanie Grabrucker of the Brain article entitled: Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis How does lifestyle and the environment affect cognition in Alzheimer's
Do noradrenergic alterations in Parkinson's disease indicate a therapeutic target? A combined PET & neuromelanin MRI study
Welcome to the 17th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with senior author Dr Bénédicte Ballanger of the Brain article entitled: Noradrenergic alterations in Parkinson's disease: a combined 11C-yohimbine PET/neuromelanin MRI study Can this multi-modal study examining the role of Noradrenaline in Par
Altered brain glucose metabolism as a mechanism for delirium?
Welcome to the 16th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. We are very excited to feature a January issue Brain article, where we speak with senior author Dr Lasse M Giil entitled: Impaired glucose utilization in the brain of patients with delirium following hip fracture Delirium is a common condition with significant impact on patient
Are there differences in the immune response among individuals of Black ethnicity with multiple sclerosis?
Welcome to the 15th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. We are very excited to feature our first article from Brain Communications, where we speak with first author Dr Kiel Telesford of the article entitled: Neuron-binding antibody responses are associated with Black ethnicity in multiple sclerosis during natalizumab treatment This e
Exploring a genetic basis for disordered speech and language: FOXP2 mutations and striatal neurons
Welcome to the 14th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. In this episode we speak with Fu-Chin Liu, senior author of the article entitled: Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons. This article explores a potential genetic basis for disordered speech by a mutation in the transcription fact
Multisite thalamic recordings to characterize seizure propagation in the human brain
Welcome to the 13th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. In this episode we speak with Josef Parvizi, senior author of the article entitled: Multisite thalamic recordings to characterize seizure propagation in the human brain This article explores the role of the thalamus in seizure propagation and how multi-site intracranial electrod
A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies
Welcome to the 12th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. In this episode we speak with Nico Melzer, senior author of the article entitled: A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies This article explores expanding entity of GAD-65 associated neurological syndromes, the exciting
RNA profiling of human dorsal root ganglia reveals sex differences in mechanisms promoting neuropathic pain
Welcome to the 11th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. In this episode we speak with Ted Price, senior author of the article entitled: RNA profiling of human dorsal root ganglia (DRG) reveals sex differences in mechanisms promoting neuropathic pain This article explores exciting findings around differences in the DRG transcriptome w
Tau positron emission tomography in preclinical Alzheimer's disease
Welcome to the 11th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. In this episode we speak with Philip Insel, lead author of the article entitled: Tau positron emission tomography in preclinical Alzheimer's disease The article explores the utility of tau PET imaging in three independent, large cohorts of cognitively normal individuals with high
Intrinsic blood–brain barrier dysfunction contributes to multiple sclerosis pathogenesis
Welcome to the 10th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. In this episode we speak with Hideaki Nishihara and Britta Engelhardt, lead authors of the article entitled: Intrinsic blood–brain barrier dysfunction contributes to multiple sclerosis pathogenesis This was a transcontinental recording with our guests dialing in from Japan and Eu
COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis
Welcome to the 9th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. In this episode we chat with Professor Robyn S. Klein, senior author of the article entitled: COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis This article explores the ongoing challenge to better understand the mechanisms underlying the cognitive and
Gene variant effects across sodium channelopathies predict function and guide precision therapy
Welcome to another episode of The Brain Podcast (first for 2023!) - the official podcast for the journal Brain and sister journal Brain Communications. In this episode, three guests joined us to discuss the article entitled: Gene variant effects across sodium channelopathies predict function and guide precision therapy. Professor Andreas Brunklaus (first author) and Professor Stephanie Schorge (se
A daily temperature rhythm in the human brain predicts survival after brain injury
Welcome to the seventh episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. In this episode we chat with Dr Nina M Rzechorzek, lead author of the article entitled: A daily temperature rhythm in the human brain predicts survival after brain injury We discuss how brain temperature was measured using invasive and non-invasive methods to identify a physio
Seronegative autoimmune encephalitis: clinical characteristics and factors associated with outcomes
Welcome to The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications. In this episode we are joined by Professor Soon-Tae Lee to discuss his review article entitled Seronegative autoimmune encephalitis: clinical characteristics and factors associated with outcomes. Read the full article on the Brain website: https://doi.org/10.1093/brain/awac166 Maarten
Cortical involvement and upcoming therapies in Multiple Sclerosis
Welcome to The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications. In this episode we are joined by Associate Professor Pavan Bhargava to discuss his review article entitled The contribution of B cells to the cortical damage in multiple sclerosis. Read the full article on the Brain website: https://doi.org/10.1093/brain/awac233 This episode was hos
Tau measurements from skin biopsy to distinguish primary taupathies and alpha-synucleinopathies
Welcome to The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications. In this episode we chat with Dr Georgia Melli, senior author of the article entitled: Tau protein quantification in skin biopsies differentiates tauopathies from alpha-synucleinopathies She discusses the use of skin biopsy to quantify pathological tau protein as an accessible and usef
Focused ultrasound to improve blood-brain barrier penetration of a novel therapeutic for Alzheimer's pathology
Welcome to the third episode of The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications. In this episode we chat with Dr Kristiana Xhima and Professor Isabelle Aubert, lead and senior authors, respectively, of the article entitled: Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies. They discuss the excit
Neuropathological fingerprints of survival, atrophy and language in primary progressive aphasia
Welcome to another episode of The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications. We are joined by Professor Marsel Mesulam who will discuss his masterclass in clinico-pathological-neuroimaging analysis of primary progressive aphasias. Check out the full article on the Brain website: https://doi.org/10.1093/brain/awab410 This episode was hosted,
Modelling narcolepsy induced by influenza vaccination
Welcome to the first episode of the Brain podcast- the official podcast for the journal Brain and sister journal Brain Communications. We are joined by Professor Roland Liblau who will tell us about his group's mouse model of narcolepsy in which autoimmune inflammation of orexinergic neurons is induced by influenza vaccination. Check out the full article on the Brain website: https://academic.oup
Recommended
Easy English: Learn English with everyday conversations
SAS: The Shadow War
Esme's Country Life
Miles From Ordinary Podcast
Off The Telly
Murder of a Famous Bastard
Learn UK English By Podcast
My IELTS Classroom Podcast
People Fixing the World
The History Hour
The Healing Childhood Trauma Podcast
Frank Off The Radio: The Frank Skinner Podcast
