
The Lancet Healthy Longevity in conversation with
Editors at The Lancet Healthy Longevity talk with the journal’s authors about their latest research and its implications for health, healthcare, and policy. This monthly audio companion to the open access journal covers a wide range of topics, including dementia prevention, older people in the criminal justice system, haematological malignancies in older adults, and the relationship between physical activity, sleep duration, and cognitive ageing. Each episode explores how new findings may shape clinical practice and public health. The podcast is produced by The Lancet Group.
Episodes

Metformin as an adjunctive therapy to an intensive lifestyle intervention in older adults with obesity with Dennis Villareal
Metformin has received a lot of attention in the field of ageing, though clinical trials remain scarce. Dennis Villareal (Michael E. DeBakey VA Medical Center, Houston, USA) discusses the DEMFOS trial assessingl assessing whether adding metformin to an intensive lifestyle intervention can improve physical functioning in older adults with obesity and functional impairment.
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Ara Nazarian on musculoskeletal diseases in the USA
The burden of musculoskeletal diseases is increasing. Dr Ara Nazarian tells us more about the issues surrounding this and how care can be improved in the USA.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(25)00026-1/fulltext?dgcid=buzzsprout_icw_podcast_Jun_25_lanhl
Also discussed, the ecological study in The Lancet Regional Health Americas:
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Andrew Kingston on socioeconomic inequalities and disability
Socioeconomic status impacts the onset and duration of severe disabilities, but what does this means for public health policy?
Andrew Kingston (Newcastle University, UK) talks to Editor-in-Chief of The Lancet Healthy Longevity Philippa Harris about his study on socioeconomic inequalities in disability-free life expectancy in England.
Read the full article:
https://www.thelancet.com/journals/lanhl

Miles Witham on metformin to improve physical performance
Miles Witham discusses his trial on the use of metformin to improve physical performance in older adults with sarcopenia and prefrailty or frailty.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(25)00014-5/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanhl
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Harish Nair and Durga Kulkarni on the human metapneumovirus burden in older adults globally
Professor Harish Nair and Durga Kulkarni (University of Edinburgh) discuss their systematic review and meta-analysis on the global burden of human metapneumovirus-associated respiratory infections in older adults.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(24)00205-8/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanhl
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Dannii Yuen-Lan Yeung and Da Jiang on a the benefits of a volunteering intervention for lonely older adults
Prof. Dannii Yuen-Lan Yeung & Dr. Da Jiang discuss the benefits of a volunteering intervention in mitigating loneliness in older volunteers.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(24)00190-9/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanhl
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Antonia Clarke on dementia prevalence in Indigenous populations
Antonia Clarke (Monash University, Australia) joins Editor-in-Chief Philippa Harris to discuss her systematic review on dementia prevalence in Indigenous populations in countries with a very high Human Development Index.
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Dr Iracema Leroi on a hearing and vision rehabilitation intervention for people with dementia
Dr Iracema Leroi discusses the SENSE-Cog trial on the effects of a hearing and vision rehabilitation and support programme on quality of life in people living with dementia.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(24)00141-7/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanhl
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Juan Fortea on biomarkers of neurodegeneration
Juan Fortea joins Editor-in-Chief Philippa Harris to discuss the joint The Lancet Healthy Longevity and eBioMedicine Series on biomarkers of neurodegeneration.
Read the Series:
https://www.thelancet.com/series/biomarkers-of-neurodegeneration?dgcid=buzzsprout_icw_podcast_generic_lanhl
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Dina Goodman-Palmer on frailty in rural Burkina Faso
Dr Dina Goodman-Palmer discusses her study on frailty progression in adults living in rural Burkina Faso.
Read the full article:
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(24)00096-5?dgcid=buzzsprout_tlv_podcast_generic_lanhl
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Professor Joël Guigay on clinical trials of older patients with head and neck cancer
Joël Guigay discusses the ELAN-FIT and ELAN-UNFIT trials in older people with head and neck cancer, published in The Lancet Healthy Longevity, and the importance of geriatric assessments in clinical trials of older cancer patients.
Read the full articles:
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00284-2/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanhl
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Jonas Salling Quist on time-restricted eating
Jonas Salling Quist talks about his trial on the effects of time-restricted eating on bodyweight and cardiometabolic health for individuals at risk of type 2 diabetes.
Read the full article:
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(24)00028-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanhl
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Lara Pivodic on social connections at the end of life
Professor Lara Pivodic discusses her publication in The Lancet Healthy Longevity on social connections in the final years of life and how these connections predict end-of-life outcomes.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(24)00011-4/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanhl
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Helena Carreira on fracture risk in cancer survivors
Helena Carreira discuses her recent work on the risk of fractures in half a million survivors of 20 cancers in England.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00285-4/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanhl
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David Ekers, Simon Gilbody, and Judith Webster on the BASIL trial
David Ekers, Simon Gilbody, and Judith Webster discuss the BASIL trial on behavioural activation to prevent depression and loneliness among socially isolated older people with long-term health conditions.
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Elburg van Boetzelaer and Favila Escobio on the exclusion of older people during humanitarian emergencies
Elburg van Boetzelaer, joined by Favila Escobio, discusses her recent publication in The Lancet Healthy Longevity on involving older people in the preparedness, response, and recovery phrases of humanitarian emergencies.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00244-1/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanhl
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Kathy Liu on evaluating the clinical benefit of treatments for Alzheimer’s disease
Kathy Liu discusses her publication in The Lancet Healthy Longevity on how to evaluate the clinical benefits of treatments for Alzheimer’s disease.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00193-9/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanhl
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Magdalena Taube on haematological cancer following bariatric surgery
Magdalena Taube discusses her work on haematological cancer following bariatric surgery with The Lancet Healthy Longevity Editor-in-Chief Philippa Harris.
Read the full article:
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00141-1/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanhl
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Lindsay Kobayashi on negative wealth shocks in later life and subsequent cognitive function
Lindsay Kobayashi talks with Editor-in-Chief Philippa Harris about her Article in The Lancet Healthy Longevity on negative wealth shocks in later life and subsequent cognitive function.
Read the full article:
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00113-7/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanhl
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Amanda Perry on older people in the criminal justice system
Amanda Perry discusses her paper on interventions for depression and anxiety in older people with physical health problems in the criminal justice system.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00111-3/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanhl
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Mikaela Bloomberg on physical activity, sleep duration, and cognitive ageing
Dr Mikaela Bloomberg talks about her paper in The Lancet Healthy Longevity on joint associations of physical activity and sleep duration with cognitive ageing.
Read the full article:
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00083-1/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanhl
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Sawsan Abdulrahim and Stephen J McCall on COVID-19 vaccination of Syrian refugees
Sawsan Abdulrahim and Stephen J McCall discuss their paper published in The Lancet Healthy Longevity on COVID-19 vaccination of older Syrian refugees in Lebanon.
Read the full article:
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00038-7/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanhl
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Suraj Samtani on associations between social connections and cognition
Dr. Samtani discusses his new paper published in The Lancet Healthy Longevity on associations between social connections and cognition
Read the full article:
Associations between social connections and cognition: a global collaborative individual participant data meta-analysis
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Madeline Meier on healthy ageing in long-term cannabis users
Prof. Meier discusses her new paper published in The Lancet Healthy Longevity on preparedness for healthy ageing in long-term cannabis users.
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Preparedness for healthy ageing and polysubstance use in long-term cannabis users
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Dr. Luigi Ferrucci on improving care of older patients with complex multimorbidity and frailty.
Dr. Luigi Ferrucci, Scientific Director of the US National Institute on Aging, discusses his new Comment published in The Lancet Healthy Longevity on a call to action for better care of older patients with complex multimorbidity and frailty.
Read the Comment in The Lancet Healthy Longevity: https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(22)00173-8/fulltext
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Christopher Mikton on elder abuse
Dr Christopher Mikton discusses his and his collaborators’ new study published in The Lancet Healthy Longevity on the factors influencing the global prioritisation of elder abuse.
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Factors shaping the global political priority of addressing elder abuse: a qualitative policy analysis
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Hussein Yassine on dementia prevention trial design
Dr Hussein Yassine discusses the findings of the Nutrition for Dementia Prevention Working Group on the limitations of existing nutrition clinical trials for dementia prevention and corresponding recommendations for the design of future trials.
Read the full article:
Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group
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Christopher Chiu and Stephanie Ascough on respiratory syncytial virus in older adults
Professor Christopher Chiu and Dr Stephanie Ascough discuss their new paper in The Lancet Healthy Longevity on the correlates and mechanisms of protection against respiratory syncytial virus in older adults.
Read the full article:
Divergent age-related humoral correlates of protection against respiratory syncytial virus infection in older and young adults: a pilot, controlled, human infection cha

Dr Sophie Vieujean on older adults with IBD and clinical trials
Dr Sophie Vieujean (Liège University Hospital) joins Ben Burwood to discuss her Review detailing the issues facing the inclusion of older adults with inflammatory bowel disease in clinical trials.
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Samar Al-Hajj on injury morbidity and mortality in older people living in the Eastern Mediterranean
Dr Samar Al-Hajj discusses a recent GBD study published in The Lancet Healthy Longevity on injury morbidity and mortality in older people living in the Eastern Mediterranean region.
Read the full article:
Injury burden in individuals aged 50 years or older in the Eastern Mediterranean region, 1990–2019
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Amy Justice on ageing with HIV
Dr Amy Justice (Yale University, USA) talks to Philippa Harris about the joint The Lancet HIV and The Lancet Healthy Longevity Series Ageing with HIV.
Read the Series:
Ageing with HIV
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Yao Yao on China’s Clean Air Act and cognitive function in older adults
Dr Yao Yao discusses his and his collaborators’ study, published in The Lancet Healthy Longevity, on the effects of China’s Clean Air Act on cognitive function in older adults.
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The effect of China's Clean Air Act on cognitive function in older adults
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Jacqueline Ramke on global eye health and ageing
Dr. Jacqueline Ramke discusses her and her collaborators’ study, published in The Lancet Healthy Longevity, on the key challenges in global eye health and the importance of addressing these in the context of population ageing.
Read the full article:
Grand Challenges in global eye health: a global prioritisation process using Delphi method
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Andrew J. Scott on achieving a longevity society
Professor Andrew J. Scott discusses his two Health Policy papers, published in The Lancet Healthy Longevity, on the importance of achieving a longevity society and longevity economy.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00247-6/fulltext
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Raul Cordoba on haematological malignancies in older people
Dr Raul Cordoba discusses the joint Series between The Lancet Healthy Longevity and The Lancet Haematology on haematological malignancies in older people.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00184-7/fulltext
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Michaël Boissonneault on unhealthy working life expectancy
Dr Michaël Boissonneault discusses his recent study published in The Lancet Healthy Longevity on changes over time in unhealthy working life expectancy and related implications for policy and practice.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00202-6/fulltext
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Alex Jadad on the conditions for a good death
Professor Alex Jadad discusses his recent review published in The Lancet Healthy Longevity on the conditions for a good death.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00097-0/fulltext
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Jack Rowe on gender differences in societal ageing
Professor Jack Rowe discusses his and his collaborators’ study, published in The Lancet Healthy Longevity, on gender differences in societal ageing across 18 different countries.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00121-5/fulltext
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Peter Hanlon on representation of older people in clinical trials
Dr Peter Hanlon talks with The Lancet Healthy Longevity about the representativeness of clinical trials done in older people.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00092-1/fulltext
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Laura Shallcross on SARS-CoV-2 reinfection in long term care facilities
Laura Shallcross discusses her study published in The Lancet Healthy Longevity on protective immunity against SARS-CoV-2 reinfection in seropositive staff and residents in long-term care facilities.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(20)30065-9/fulltext
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Paula Rochon on polypharmacy in older people
Dr Paula Rochon talks with The Lancet Healthy Longevity about polypharmacy in older people through a sex and gender lens.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00054-4/fulltext
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Jendé Zijlmans and Annemarie Luik on frailty
Dr Jendé Zijlmans and Dr Annemarie Luik discuss the interaction of cognitive reserve and brain reserve with frailty and the association with mortality risk.
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https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00028-3/fulltext
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